Not by themselves.
As we explained on another page, the only factor in weight loss is consuming less calories than one needs, regardless of the make up of protein, fat, and carbohydrates. This is true for the inverse - to gain fat, you must consume more calories than you need, regardless of protein, fat, and carbohydrates content.
The process in which carbohydrates are converted into fat deposits is called de novo lipogensis (DNL).
Another study found that eating carbohydrates at night had no negative impact on fat loss.
So while carbohydrates can inhibit fat burning, putting the onus on carbohydrates themselves (instead of excessive calories) as the cause behind fat gain is incorrect.
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- De novo lipogenesis in humans: metabolic and regulatory aspects. Eur J Clin Nutr. (1999) Hellerstein MK.
- No common energy currency: de novo lipogenesis as the road less traveled. Am J Clin Nutr. (2001) Hellerstein MK.
- De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women. Am J Clin Nutr. (2001) McDevitt RM, et al.
- Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J Clin Invest. (1995) Schwarz JM, et al.
- Greater weight loss and hormonal changes after 6 months diet with carbohydrates eaten mostly at dinner. Obesity (Silver Spring). (2011) Sofer S, et al.