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Adrafinil

Adrafinil is a precursor drug to modafinil, which means adrafinil is metabolized in the body to produce modafinil. Both are stimulants with no amphetamine-like effects.

Our evidence-based analysis on adrafinil features 21 unique references to scientific papers.

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Summary of Adrafinil

Primary information, health benefits, side effects, usage, and other important details

Adrafinil is a synthetic nootropic compound. It is a prodrug for modafinil, meaning supplementation of adrafinil leads to increased concentrations of modafinil in the body.

Adrafinil supplementation increases alertness and wakefulness. Adrafinil is a stimulant, but it does not cause hyperactivity. Instead, it fights sleepiness.

Taking adrafinil may also improve memory, but further research is needed to confirm this effect.

Adrafinil works vicariously through modafinil. Further research is needed to determine the exact mechanisms of modafinil, but preliminary evidence suggests histaminergic signaling may play a vital role.

Safety information on adrafinil is lacking because modafinil is often used instead, for treatment of narcolepsy and excessive daytime sleepiness. Long term supplementation of adrafinil is not advised, since adrafinil is metabolized into modafinil in the liver, and there is no available evidence regarding liver safety. Adrafinil and modafinil are banned by the World Anti-Doping Agency (WADA) as a nonspecific stimulant compound.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

The standard dosage for adrafinil is reported to be 600-1,200mg, which for the purpose of treating narcolepsy was either 600mg twice daily (morning and midday) or 600-900mg taken once daily upon waking. Adrafinil is no longer used for this purpose due to modafinil being a more suitable pharmaceutical, and these doses reflect the recommendations for the prescription drug Olmifon when it was available.

Adrafinil should not be taken in the afternoon and evening, since supplementation would impair sleep. Adrafinil tends to be taken three times a week, for no longer than five months.

Things to Note

Is a Form Of

Primary Function:

Also Known As

Olmifon, CRL-40028

Do Not Confuse With

Modafinil

  • Adrafinil is classified as a nonspecific stimulant and banned by WADA under section 6 of the 2014 banned substances list[1]

  • Due to its antisleep effects and long half-life, adrafinil should not be taken at any time aside from immediately in the morning if proper sleep is desired

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Click here to see all 21 references.