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BPC-157

BPC-157 is a synthetic peptide that is being investigated for its regenerative effects. It shows high efficacy for rats suffering toxic or surgical trauma, but there is currently no evidence that it provides benefits for people.

Our evidence-based analysis on bpc-157 features 36 unique references to scientific papers.

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Summary of BPC-157

Primary information, health benefits, side effects, usage, and other important details

BPC-157 is a peptide chain consisting of 15 amino acids. It is considered synthetic because this particular sequence does not exist in nature. It is derived from a protective protein found in the stomach.

Researchers have conducted numerous rodent studies on BPC-157 that show it has protective effects extending beyond the stomach and intestinal tract. BPC-157 has been shown to benefit ulcers in the stomach, intestinal damage such as fistulas and inflammatory disorders, bone and joint healing and growth rates, and organ damage. It also has some influences on the brain. Researchers have observed marked protective effects when BPC-157 is administired to rats alongside a research toxin or damaging surgical procedure.

More research is needed to clarify whether BPC-157 has multiple mechanisms of action, but current research suggests BPC-157 influences several growth factors usually involved in angiogenesis (the production of blood vessels) and other factors involved in regeneration following damage.

BPC-157 shows promise, but human studies are needed to demonstrate that these benefits extend beyond research animals.

The majority of studies on BPC-157 are done on rats given injections of the supplement. While BPC-157 is a stable peptide, peptides are a group of compounds that are normally poorly absorbed after oral supplementation, so researchers use injections in rodent studies instead. Furthermore, there is no human evidence for BPC-157 and the majority of the research has been conducted by a single research group. Due to its synthetic nature, there may be legal issues associated with the sale of this supplement in certain regions and it may be banned by some sport organizations.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

The closest possible recommended dose is based on rat studies where oral administration showed benefit, as most studies administer the supplement via injection. The oral dose that was effective in rats, 10 μg/kg, is estimated to be equivalent to 1.6 μg/kg, or:

  • 110 μg for a 150lb person

  • 145 μg for a 200lb person

  • 180 μg for a 250lb person

There are currently no human pharmacokinetic studies to assess species differences.

Things to Note

Primary Function:

Also Known As

PL 14736, PL-10, Bepecin

Do Not Confuse With

TB-500

Caution Notice

  • Due to the current status as a synthetic substance (not occurring in nature) BPC-157 may not be WADA approved; use with caution

  • BPC-157 is a patented supplement and there may be crossover between those mentioned in the patent and the researchers of many of the relevant studies.[1]

  • BPC-157 is a synthetic substance (not occurring in nature) and may not be WADA approved

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Click here to see all 36 references.