Quick Navigation

D-Serine

D-Serine is an amino acid that plays a role in cognitive enhancement and schizophrenia treatment.

Our evidence-based analysis on d-serine features 158 unique references to scientific papers.

Research analysis led by .
Reviewed by
www.blogrefugio.com Team
Last Updated:

Summary of D-Serine

Primary information, health benefits, side effects, usage, and other important details

D-Serine is an amino acid found in the brain. Derived from glycine, d-serine is a neuromodulator, meaning it regulates the activities of neurons.

D-Serine supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced N-methyl-D-aspartate (NMDA) signaling, which includes cocaine dependence and schizophrenia.

D-Serine’s effect on schizophrenia is well researched, and though it shows promise, it is also unreliable, since d-serine does not always reach the blood after supplementation. Sarcosine may be a more reliable treatment.

D-Serine is a coagonist at NDMA receptors, which means it improves the effects of other compounds that bind with the receptor. These compounds include glutamate and NMDA itself.

D-Serine is often categorized as a nootropic.

Get trusted answers to health questions that matter to you

Getting an www.blogrefugio.com subscription makes it easy for you to stay informed and understand the latest nutrition research.

If you’re overwhelmed by all the possibilities of supplementation and want step-by-step instructions on what supplements to take (how much, when, and in what combinations), then the www.blogrefugio.com Supplement Guides are perfect for you.

Your support keeps us 100% independent, so that we never have a conflict of interest.


How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

The usual dose used in D-serine studies is 30mg/kg of bodyweight. This correlates to an approximate dosage range of 2,045 – 2,727mg for people between 150 – 200 lbs. This dose appears to be the minimal effective dose for improving cognition in people suffering from a variety of diseases.

Preliminary evidence suggests that doubling or quadrupling the dosage to 60mg/kg and 120mg/kg, respectively, will cause additional benefits for people suffering from schizophrenia.

?? Don't waste your time on outdated information: Get Examine Personalized for access to the latest research on 400+ supplements and their effects on 600+ health outcomes.

Already a member? Click here to log in.

Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects D-Serine has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 3 studies
There may be an improvement in cognitive performance secondary to reducing symptoms of schizophrenia, and while there is mechanistic plausibility that this can also work in normal controls it has not yet been demonstrated
grade-b Minor Moderate See all 6 studies
D-Serine supplementation is able to reduce symptoms of schizophrenia (more efficacy on negative and cognitive symptoms rather than positive) in a dose-dependent manner between 30-120mg/kg, but possibly due to the unreliable increases in blood D-serine its benefits are also unreliable
grade-c Minor - See study
When taken 2 hours prior to testing, 2.1g D-serine seems effective in reducing anxiety during testing in otherwise healthy humans
grade-c Minor - See study
There was an increase in sustained attention during cognitive testing in otherwise healthy subjects given 2.1g D-serine prior to testing, as assessed by CPT-IP.
grade-c Minor - See study
Reported sadness during cognitive testing appears to be reduced with D-serine supplementation when compared to placebo
grade-c Minor - See study
Preliminary evidence suggests that the standard dosage of D-Serine can alleviate some symptoms of Parkinson's disease
grade-c Minor - See study
One study using 20mg/kg D-serine in subjects with PTSD noted benefits with supplementation when compared to placebo.
grade-c Minor - See study
Immediate recall appears to be increased from D-serine when 2.1g is supplemented 2 hours prior to testing.
grade-c - - See study
When 2.1g D-serine is taken two hours prior to cognitive testing, there does not appear to be an increase in reaction time when compared to placebo
grade-c - - See study
2.1g D-serine in otherwise healthy humans does not acutely influence serum BDNF concentrations
grade-c - - See study
In a category fluency test, 2.1g D-serine taken two hours earlier appears to improve fluency. The increase was larger than seen with placebo, but comparing the two groups did not yield a significant benefit with D-serine over placebo statistically

Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more.

Becoming an Examine subscriber unlocks the Human Effect Matrix for supplements, as well as all health topics on www.blogrefugio.com. We summarize all the latest research so that you can make the best decisions for your health based on accurate and not up-to-date information.

Plus, you get a monthly summary of the latest research on the health topics you care about.

Things to Note

Do Not Confuse With

Glycine or Sarcosine (similar in mechanisms), Phosphatidylserine (a phospholipid containing L-serine)

Get our free 5-day course on the essentials of supplementation.

At www.blogrefugio.com, our incentives line up with yours — getting unbiased information. That's why we don’t sell any advertising or supplements.

Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy.

Click here to see all 158 references.