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Hypericum perforatum

Hypericum Perforatum (St. John's Wort) is an anti-depressant herb that is commonly used for its neurological effects. While it appears effective, it is well known to adversely interact with a variety of pharmaceuticals.

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Summary of Hypericum perforatum

Primary information, health benefits, side effects, usage, and other important details

St. John's Wort (Hypericum perforatum) is a herb which, through the active component hypericin, works as a dopamine-related anti-depressant and is effective at doing so. This is also the prototypical 'adverse drug-interaction' herb; it interacts with several compounds by affecting the several phase I enzymes as well as other drug elimination pathways.

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Things to Note

Primary Function:

Also Known As

St. John's Wort

Caution Notice

St. John's Wort interferes with the elimination of several drugs and supplements. It is a significant CYP3A4 inducer, and should not be used with pharmaceuticals or supplements that are metabolized by this enzyme (like berberine). Consult a medical professional before supplementation of St. John's Wort if you are taking any drugs or supplements.

  • St. John's Wort induces (increases the amount of) CYP3A4, and should not be used by pharmaceuticals that are metabolized by this enzyme

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Click here to see all 85 references.