Supplementation of MSM tends to be taken at up to 3,000mg daily, which seems to be effective for reducing symptoms of osteoarthritis and conferring some antioxidant protection to the body. It is unsure if higher supplemental doses are better than 3,000mg, so sticking to that dose may be prudent.
Methylsulfonylmethane
Our evidence-based analysis on methylsulfonylmethane features 75 unique references to scientific papers.
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Human Effect Matrix
Unlocked for Examine membersThe Human Effect Matrix summarizes human studies to tell you what effects Methylsulfonylmethane has on your body, how much evidence there is, and how strong these effects are.
Full details are available to Examine members.
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
|
Multiple studies where at least two are double-blind and placebo controlled |
|
Single double-blind study or multiple cohort studies |
|
Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Outcome |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
|
|
Notable
|
- See study |
A decrease in exercise induced oxidation is noted with MSM supplementation and thought to be the underlying reason for reductions in muscle damage and soreness. The degree of reduction seems to be notable, as the increase in MDA and protein carbonylation were fully abolished
|
|
|
|
Minor
|
- See study |
One study that used MSM as a placebo noted that there was an increase in edema relative to baseline; not known why.
|
|
|
|
Minor
|
Very High See 2 studies |
A reduction in oxidative biomarkers has been noted following MSM ingestion
|
|
|
|
Minor
|
- See study |
A decrease in exercise-induced lipid peroxidation is noted as assessed by serum MDA
|
|
|
|
Minor
|
- See study |
Biomarkers of muscle damage such as creatinine and bilirubin are decreased following exercise with an MSM preload
|
|
|
|
Minor
|
- See study |
A decrease in muscle soreness has been noted with MSM preloads before exercise
|
|
|
|
Minor
|
- See study |
A decrease in protein carbonylation is noted with MSM supplementation
|
|
|
|
Minor
|
- See study |
A decrease in symptoms of osteoarthritis has been noted and seems to be somewhat comparable in potency to glucosamine sulfate
|
|
|
|
- | - See study |
No significant influence on exercise related fatigue
|
|
|
|
- | - See study |
No significant influence on pain symptoms in osteoarthritis
|
|
|
|
- | - See study |
No significant influence on the total training volume able to be conducted
|
|
|
|
Minor
|
- See study |
A decrease in pollen-induced allergies has been noted with MSM supplementation, with efficacy within one week
|
|
|
|
Minor
|
- See study |
Decreases upper respiratory symptoms have been noted with MSM supplementation, although not to a remarkable degree.
|
Studies Excluded from Consideration
Confounded with Milk Thistle bioactives[3]
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Things to Note
Other Functions:
Primary Function:
Also Known As
MSM, dimethyl sulfone, dimethylsulfone
Do Not Confuse With
DMSO (reduced form of MSM)
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Click here to see all 75 references.
