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Stinging Nettle

Stinging Nettle is quite a nasty plant to touch, but oral ingestion of pills without spikes results in a moderately potent anti-inflammatory that can reduce the sniffles. Does not boost testosterone despite being claims to, although it can help Benign Prostatic Hyperplasia and urine abnormalities.

Our evidence-based analysis on stinging nettle features 43 unique references to scientific papers.

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Last Updated:

How to Take

Recommended dosage, active amounts, other details

120mg of Stinging Nettle (root) taken three times a day (totalling 360mg) is associated with benefit in Benign Prostate Hyperplasia.

For allergies, the studied dosage is 300 mg twice a day of freeze-dried nettle leaf.

The evidence is much better for nettle root and prostatic enlargement than for nettle leaf and allergies.

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Stinging Nettle has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor - See study
A small decrease in allergic symptoms with oral stinging nettle consumption
grade-c Minor - See study
An increase in glutathione peroxidase has been detected
grade-c Minor - See study
Minor decrease in C-reactive protein concentrations
grade-c Minor Very High See 2 studies
Appears to reduce LPS-stimulated proinflammatory cytokine release, and thus is likely to have anti-inflammatory effects. The potency of this is not overly remarkable
grade-c Minor - See study
A slight decrease in nasal congestion seen with stinging nettle
grade-c Minor - See study
Appears to increase urinary flow rate in persons with benign prostatic hyperplasia
grade-c - - See study
No significant interactions between insulin sensitivity and stinging nettle yet detected
grade-c - - See study
No significant effect on lipid peroxidation has been noted.
grade-c - - See study
No significant influence on prostatic hypertrophy despite reducing symptoms
grade-c - - See all 4 studies
Highly difficult to assess the efficacy of stinging nettle on osteoarthritic symptoms due to a wide degree of variance in study methodology
grade-c - - See study
No apparent effect on circulating TNF-a at baseline (may reduce TNF-a secretion from proinflammatory signals, see inflammation)
grade-c - - See study
No detectable influence on testosterone levels
grade-c - - See study
No significant influence on body weight with consumption of stinging nettle

Studies Excluded from Consideration

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Things to Note

Is a Form Of

Primary Function:

Also Known As

Urtica dioica, Radix Urticae, Common Nettle, Greater Nettle, Ortica, Tsuknida

  • Quite a bit of the trials decided to just throw in multiple herbs, so benefits seen cannot be attributed to Urtica Dioica in isolation for these studies

  • Apparently, rubbing the leaves of Urtica Dioica onto sore joints (despite supplements being from the roots, due to higher levels of active ingredients) might aid in joint pain

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Click here to see all 43 references.