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Uridine

Uridine is a nucleotide base found in high levels in beer which is used for increasing synthesis of cellular membranes and for other neurological properties. It appears to have potentially cognitive enhancing properties, and is synergistic with fish oil.

Our evidence-based analysis on uridine features 107 unique references to scientific papers.

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Last Updated:

How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

Supplementation of uridine seems to be in the 500-1,000mg range, with the lone human study using the higher end of this range. It is recommended to take uridine with food out of prudency, but this has not been noted to be an absolute requirement.

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Uridine has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d Minor - See study
Depressive symptoms in bipolar disorder have been noted to be reduced
grade-d Minor - See study
Depressive symptoms of bipolar disorder are fairly strongly reduced with uridine supplementation, but currently only open label studies are in existence

Studies Excluded from Consideration

  • Highly confounded with other nootropic compounds[1]

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Things to Note

Is a Form Of

Also Known As

UDP, UMP

Goes Well With

  • Fish Oil (Specifically DHA, for cognition)

  • Choline or other cholinergics (Cognition)

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Click here to see all 107 references.