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HbA1c

HbA1c (glycated hemoglobin) is a biomarker of glucose metabolism — it reflects glucose levels over months. Higher HbA1c is associated with more disease progression and comorbidities in states of insulin resistance or diabetes.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect HbA1c.

Full details on all HbA1c supplements are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a - Very High See all 18 studies
Although sporadic evidence suggest improvements in HbA1c in diabetics, the entirety of the evidence does not support a reliable and significant improvement in diabetic persons.
grade-a - Moderate See all 10 studies
Although the majority of evidence suggests absolutely no influence on HbA1c, reductions have been reported and a lone case has noted a clinically irrelevant increase of HbA1c (secondary to the increase in glucose). Practically, there is unlikely to be any large changes
grade-b Strong Very High See all 3 studies
The reduction of HbA1c associated with berberine, according to a meta-analysis of diabetics using 1,000-1,500mg berberine daily, was −0.72% (95% CI −0.97 to −0.47) more than placebo. This reduction appears to be one of the more significant reductions associated with dietary supplements.

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