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Liver Enzymes

Liver enzymes are used as biomarkers to test the toxicity of a supplement and are elevated in case of fatty or cirrhotic liver. Lower blood levels are thought to reflect less-damaged liver cells.

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Summary of Liver Enzymes

The most common liver enzymes are aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transpeptidase (GGT).

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Liver Enzymes.

Full details on all Liver Enzymes supplements are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 5 studies
The decrease in liver enzymes associated with cholestasis is quite strong, and TUDCA is a reference drug for these effects
grade-b Notable Low See all 9 studies
There appears to be a notable decrease in both ALT and γ-GPT in persons with non-alcoholic fatty liver (NAFLD) which may exceed 50% when vitamin E is supplemented above 300mg for half a year; there does not appear to be any influence whatsoever in healthy controls.
grade-b Minor Moderate See all 16 studies
No significant influence on liver enzymes associated with curcumin supplementation in most people, however, a small reduction is more likely in people with elevated liver enzymes.

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